Assay Detail
Binding
CHEMBL667865
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Inhibition of rat liver Dihydrofolate reductase.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.28 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174091 | — | — | 1 | 4.82 |
| CHEMBL279509 | — | — | 1 | 4.33 |
| CHEMBL367061 | — | — | 1 | 4.30 |
| CHEMBL172808 | — | — | 1 | 4.27 |
| CHEMBL366869 | — | — | 1 | 4.16 |
| CHEMBL287241 | — | — | 1 | 4.05 |
| CHEMBL1181 | 4-HYDROXYTRIMETHOPRIM | — | 1 | 4.04 |
| CHEMBL105006 | — | — | 1 | - |
| CHEMBL369211 | — | — | 1 | - |
| CHEMBL318078 | — | — | 1 | - |
| CHEMBL173901 | — | — | 1 | - |
| CHEMBL176489 | — | — | 1 | - |
| CHEMBL366561 | — | — | 1 | - |
| CHEMBL173709 | — | — | 1 | - |
| CHEMBL263732 | — | — | 1 | - |
| CHEMBL369057 | — | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL174309 | — | — | 1 | - |
| CHEMBL174433 | — | — | 1 | - |
| CHEMBL367218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174091 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL279509 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL367061 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL172808 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL366869 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL287241 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1181 | 4-HYDROXYTRIMETHOPRIM | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL105006 | — | IC50 | = | 296000.0 | nM | - |
| CHEMBL369211 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL318078 | — | IC50 | = | 1100000.0 | nM | - |
| CHEMBL173901 | — | IC50 | = | 580000.0 | nM | - |
| CHEMBL176489 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL366561 | — | IC50 | > | 440000.0 | nM | - |
| CHEMBL173709 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL263732 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL369057 | — | IC50 | = | 560000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 260000.0 | nM | - |
| CHEMBL174309 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL174433 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL367218 | — | IC50 | = | 600000.0 | nM | - |