Assay Detail
Binding
CHEMBL668099
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Inhibition of dihydrofolate reductase in Candida albicans (in vitro).
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.09 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121669 | — | — | 1 | 8.52 |
| CHEMBL329985 | — | — | 1 | 8.10 |
| CHEMBL330868 | — | — | 1 | 7.70 |
| CHEMBL83547 | — | — | 1 | 7.64 |
| CHEMBL121057 | — | — | 1 | 7.58 |
| CHEMBL310759 | — | — | 1 | 7.52 |
| CHEMBL118316 | — | — | 1 | 7.52 |
| CHEMBL100239 | — | — | 1 | 7.47 |
| CHEMBL123353 | — | — | 1 | 7.47 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.40 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.40 |
| CHEMBL120924 | — | — | 1 | 7.40 |
| CHEMBL121595 | — | — | 1 | 7.40 |
| CHEMBL338742 | — | — | 1 | 7.38 |
| CHEMBL334017 | — | — | 1 | 7.30 |
| CHEMBL121644 | — | — | 1 | 7.30 |
| CHEMBL122647 | — | — | 1 | 7.30 |
| CHEMBL118490 | — | — | 1 | 7.30 |
| CHEMBL420721 | — | — | 1 | 7.24 |
| CHEMBL334307 | — | — | 1 | 7.22 |
| CHEMBL333769 | — | — | 1 | 7.22 |
| CHEMBL124304 | — | — | 1 | 7.11 |
| CHEMBL121303 | — | — | 1 | 7.00 |
| CHEMBL328827 | — | — | 1 | 6.89 |
| CHEMBL122628 | — | — | 1 | 6.85 |
| CHEMBL333976 | — | — | 1 | 6.70 |
| CHEMBL121680 | — | — | 1 | 6.64 |
| CHEMBL120588 | — | — | 1 | 6.60 |
| CHEMBL123061 | — | — | 1 | 6.52 |
| CHEMBL120783 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121669 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL329985 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL330868 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL83547 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL121057 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL310759 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL118316 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL100239 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL123353 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL120924 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL121595 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL338742 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL122647 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL121644 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL118490 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL334017 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL420721 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL334307 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL333769 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL124304 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL121303 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL328827 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL122628 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL333976 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL121680 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL120588 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL123061 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL120783 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL413110 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 50000.0 | nM | 4.30 |