Assay Detail
Binding
CHEMBL668100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.59 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30938 | — | — | 1 | 7.58 |
| CHEMBL426584 | — | — | 1 | 7.51 |
| CHEMBL176848 | — | — | 1 | 7.33 |
| CHEMBL369645 | — | — | 1 | 7.21 |
| CHEMBL367882 | — | — | 1 | 7.11 |
| CHEMBL368735 | — | — | 1 | 6.54 |
| CHEMBL425506 | — | — | 1 | 6.47 |
| CHEMBL426768 | — | — | 1 | 6.37 |
| CHEMBL368759 | — | — | 1 | 6.36 |
| CHEMBL177408 | — | — | 1 | 6.31 |
| CHEMBL367220 | — | — | 1 | 6.27 |
| CHEMBL175017 | — | — | 1 | 6.24 |
| CHEMBL174954 | — | — | 1 | 6.21 |
| CHEMBL175752 | — | — | 1 | 6.14 |
| CHEMBL176217 | — | — | 1 | 6.01 |
| CHEMBL180585 | — | — | 1 | 5.91 |
| CHEMBL175577 | — | — | 1 | 5.87 |
| CHEMBL177796 | — | — | 1 | 5.86 |
| CHEMBL174633 | — | — | 1 | 5.73 |
| CHEMBL174617 | — | — | 1 | 5.55 |
| CHEMBL367308 | — | — | 1 | 5.51 |
| CHEMBL361101 | — | — | 1 | 5.47 |
| CHEMBL362254 | — | — | 1 | 5.43 |
| CHEMBL176882 | — | — | 1 | 5.38 |
| CHEMBL177125 | — | — | 1 | 5.32 |
| CHEMBL362208 | — | — | 1 | 5.24 |
| CHEMBL368065 | — | — | 1 | 5.21 |
| CHEMBL369501 | — | — | 1 | 5.18 |
| CHEMBL435553 | — | — | 1 | 5.10 |
| CHEMBL175747 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30938 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL426584 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL176848 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL369645 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL367882 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL368735 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL425506 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL426768 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL368759 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL177408 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL367220 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL175017 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL174954 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL175752 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL176217 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL180585 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL175577 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL177796 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL174633 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL174617 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL367308 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL361101 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL362254 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL176882 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL177125 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL362208 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL368065 | — | IC50 | = | 6129.0 | nM | 5.21 |
| CHEMBL369501 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL435553 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL175747 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL174753 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL177862 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL426950 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL174679 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL425152 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL177819 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL369237 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL366989 | — | IC50 | = | 53460.0 | nM | 4.27 |
| CHEMBL177230 | — | IC50 | = | 59400.0 | nM | 4.23 |
| CHEMBL174223 | — | IC50 | = | 84800.0 | nM | 4.07 |
| CHEMBL265493 | — | IC50 | = | 90450.0 | nM | 4.04 |
| CHEMBL177511 | — | IC50 | = | 125800.0 | nM | - |