Assay Detail
Binding
CHEMBL668101
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Inhibition of Dihydrofolate reductase enzyme from Candida albicans
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 9.19 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170758 | — | — | 1 | 10.52 |
| CHEMBL171305 | — | — | 1 | 9.92 |
| CHEMBL353161 | — | — | 1 | 9.80 |
| CHEMBL318721 | — | — | 1 | 9.66 |
| CHEMBL173617 | — | — | 1 | 9.66 |
| CHEMBL353621 | — | — | 1 | 9.64 |
| CHEMBL170654 | — | — | 1 | 9.48 |
| CHEMBL170144 | — | — | 1 | 9.48 |
| CHEMBL171629 | — | — | 1 | 9.42 |
| CHEMBL353763 | — | — | 1 | 9.19 |
| CHEMBL170900 | — | — | 1 | 8.89 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.72 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.72 |
| CHEMBL353929 | — | — | 1 | 8.70 |
| CHEMBL353764 | — | — | 1 | 7.64 |
| CHEMBL174414 | — | — | 1 | 7.60 |
| CHEMBL171765 | — | — | 1 | - |
| CHEMBL369258 | — | — | 1 | - |
| CHEMBL171494 | — | — | 1 | - |
| CHEMBL352960 | — | — | 1 | - |
| CHEMBL170837 | — | — | 1 | - |
| CHEMBL170760 | — | — | 1 | - |
| CHEMBL424170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170758 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL171305 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL353161 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL318721 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL173617 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL353621 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL170654 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL170144 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL171629 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL353763 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL170900 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL7492 | PIRITREXIM | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL119 | TRIMETREXATE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL353929 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL353764 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL174414 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL171765 | — | Ki | < | 0.05 | nM | - |
| CHEMBL369258 | — | Ki | < | 0.005 | nM | - |
| CHEMBL171494 | — | Ki | < | 0.11 | nM | - |
| CHEMBL352960 | — | Ki | < | 0.06 | nM | - |
| CHEMBL170837 | — | Ki | < | 0.06 | nM | - |
| CHEMBL170760 | — | Ki | < | 0.05 | nM | - |
| CHEMBL424170 | — | Ki | = | 0.0071 | nM | - |