Assay Detail
Binding
CHEMBL668102
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Inhibitory activity against Candida albicans Dihydrofolate Reductase (DHFR)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.70 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318721 | — | — | 1 | 8.40 |
| CHEMBL329985 | — | — | 1 | 8.10 |
| CHEMBL83547 | — | — | 1 | 7.64 |
| CHEMBL100239 | — | — | 1 | 7.47 |
| CHEMBL328827 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318721 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL329985 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL83547 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL100239 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL328827 | — | IC50 | = | 130.0 | nM | 6.89 |