Assay Detail
Binding
CHEMBL668118
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Inhibitory activity against Dihydrofolate reductase of Escherichia coli
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.82 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171639 | — | — | 1 | 8.40 |
| CHEMBL56282 | — | — | 1 | 8.40 |
| CHEMBL369211 | — | — | 1 | 8.38 |
| CHEMBL172805 | — | — | 1 | 8.38 |
| CHEMBL176489 | — | — | 1 | 8.30 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.30 |
| CHEMBL427305 | — | — | 1 | 8.28 |
| CHEMBL423434 | — | — | 1 | 8.20 |
| CHEMBL263732 | — | — | 1 | 8.13 |
| CHEMBL367061 | — | — | 1 | 8.11 |
| CHEMBL173641 | — | — | 1 | 8.10 |
| CHEMBL173901 | — | — | 1 | 8.00 |
| CHEMBL174433 | — | — | 1 | 8.00 |
| CHEMBL1181 | 4-HYDROXYTRIMETHOPRIM | — | 1 | 7.96 |
| CHEMBL170369 | — | — | 1 | 7.89 |
| CHEMBL173175 | — | — | 1 | 7.85 |
| CHEMBL366561 | — | — | 1 | 7.85 |
| CHEMBL173265 | — | — | 1 | 7.85 |
| CHEMBL279509 | — | — | 1 | 7.85 |
| CHEMBL367218 | — | — | 1 | 7.82 |
| CHEMBL369057 | — | — | 1 | 7.82 |
| CHEMBL174309 | — | — | 1 | 7.82 |
| CHEMBL172495 | — | — | 1 | 7.80 |
| CHEMBL322001 | — | — | 1 | 7.77 |
| CHEMBL32039 | TETROXOPRIM | 2.0 | 1 | 7.75 |
| CHEMBL366869 | — | — | 1 | 7.75 |
| CHEMBL173069 | — | — | 1 | 7.75 |
| CHEMBL105006 | — | — | 1 | 7.70 |
| CHEMBL174091 | — | — | 1 | 7.70 |
| CHEMBL174404 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171639 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL56282 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL172805 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL369211 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL176489 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL427305 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL423434 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL263732 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL367061 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL173641 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL173901 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL174433 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1181 | 4-HYDROXYTRIMETHOPRIM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL170369 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL173175 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL279509 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL173265 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL366561 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL174309 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL369057 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL367218 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL172495 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL322001 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL32039 | TETROXOPRIM | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL366869 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL173069 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL105006 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL174091 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL174404 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL173595 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL173709 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL171839 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL355793 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL172808 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL174033 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL368393 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL172131 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL287241 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL318078 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL104675 | — | IC50 | = | 320.0 | nM | 6.50 |