Assay Detail
Binding
CHEMBL668120
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Inhibition against dihydrofolate reductase enzyme of Escherichia coli
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.99 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.30 |
| CHEMBL325533 | — | — | 1 | 7.00 |
| CHEMBL339058 | — | — | 1 | 6.52 |
| CHEMBL149353 | — | — | 1 | 6.10 |
| CHEMBL150543 | — | — | 1 | 5.82 |
| CHEMBL150248 | — | — | 1 | 5.70 |
| CHEMBL357960 | — | — | 1 | 5.70 |
| CHEMBL358879 | — | — | 1 | 5.52 |
| CHEMBL149408 | — | — | 1 | 5.00 |
| CHEMBL439995 | — | — | 1 | 4.22 |
| CHEMBL150683 | — | — | 1 | - |
| CHEMBL150699 | — | — | 1 | - |
| CHEMBL150700 | — | — | 1 | - |
| CHEMBL150017 | — | — | 1 | - |
| CHEMBL150538 | — | — | 1 | - |
| CHEMBL150863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL325533 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL339058 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL149353 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL150543 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL150248 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL357960 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL358879 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL149408 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL439995 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL150683 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL150699 | — | IC50 | = | - | nM | - |
| CHEMBL150700 | — | IC50 | > | 450000.0 | nM | - |
| CHEMBL150017 | — | IC50 | = | 4500000.0 | nM | - |
| CHEMBL150538 | — | IC50 | > | 450000.0 | nM | - |
| CHEMBL150863 | — | IC50 | > | 45000.0 | nM | - |