Assay Detail
Binding
CHEMBL668121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Escherichia coli dihydrofolate reductase.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.77 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59416 | — | — | 1 | 8.92 |
| CHEMBL23338 | — | — | 1 | 8.49 |
| CHEMBL278345 | — | — | 1 | 8.43 |
| CHEMBL23609 | — | — | 1 | 8.40 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.30 |
| CHEMBL301236 | — | — | 1 | 8.16 |
| CHEMBL23746 | — | — | 1 | 8.15 |
| CHEMBL59946 | — | — | 1 | 8.09 |
| CHEMBL303075 | — | — | 1 | 8.08 |
| CHEMBL279455 | — | — | 1 | 7.92 |
| CHEMBL58550 | — | — | 1 | 7.82 |
| CHEMBL59470 | — | — | 1 | 7.62 |
| CHEMBL24503 | — | — | 1 | 7.62 |
| CHEMBL60821 | — | — | 1 | 7.44 |
| CHEMBL26337 | — | — | 1 | 7.36 |
| CHEMBL412892 | — | — | 1 | 7.27 |
| CHEMBL59369 | — | — | 1 | 7.18 |
| CHEMBL61357 | — | — | 1 | 7.14 |
| CHEMBL59952 | — | — | 1 | 6.82 |
| CHEMBL57878 | — | — | 1 | 6.22 |
| CHEMBL282022 | — | — | 1 | - |
| CHEMBL60069 | — | — | 1 | - |
| CHEMBL301030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59416 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL23338 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL278345 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL23609 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL301236 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL23746 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL59946 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL303075 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL279455 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL58550 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL59470 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL24503 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL60821 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL26337 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL412892 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL59369 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL61357 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL59952 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL57878 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL282022 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL60069 | — | IC50 | < | 4.5 | nM | - |
| CHEMBL301030 | — | IC50 | < | 5.0 | nM | - |