Assay Detail
Binding
CHEMBL668124
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Inhibitory activity to dihydrofolate reductase in Escherichia coli
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 10. 2,4-Diamino-5-(6-quinolylmethyl)- and -[(tetrahydro-6-quinolyl)methyl]pyrimidine derivatives. Further specificity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.52 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57377 | — | — | 1 | 8.72 |
| CHEMBL58455 | — | — | 1 | 8.70 |
| CHEMBL57458 | — | — | 1 | 8.62 |
| CHEMBL59491 | — | — | 1 | 8.17 |
| CHEMBL57807 | — | — | 1 | 8.13 |
| CHEMBL58038 | — | — | 1 | 8.09 |
| CHEMBL58074 | — | — | 1 | 7.92 |
| CHEMBL59283 | — | — | 1 | 7.85 |
| CHEMBL292839 | — | — | 1 | 7.80 |
| CHEMBL293325 | — | — | 1 | 7.77 |
| CHEMBL57812 | — | — | 1 | 7.72 |
| CHEMBL293977 | — | — | 1 | 7.66 |
| CHEMBL58075 | — | — | 1 | 7.64 |
| CHEMBL58744 | — | — | 1 | 7.60 |
| CHEMBL60636 | — | — | 1 | 7.52 |
| CHEMBL57900 | — | — | 1 | 7.37 |
| CHEMBL301628 | — | — | 1 | 7.36 |
| CHEMBL57829 | — | — | 1 | 7.31 |
| CHEMBL61260 | — | — | 1 | 7.24 |
| CHEMBL56652 | — | — | 1 | 7.13 |
| CHEMBL57459 | — | — | 1 | 7.05 |
| CHEMBL60632 | — | — | 1 | 6.89 |
| CHEMBL60582 | — | — | 1 | 6.81 |
| CHEMBL292621 | — | — | 1 | 6.66 |
| CHEMBL441616 | — | — | 1 | 6.54 |
| CHEMBL58917 | — | — | 1 | 6.35 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.30 |
| CHEMBL294638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57377 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL58455 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL57458 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL59491 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL57807 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL58038 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL58074 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL59283 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL292839 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL293325 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL57812 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL293977 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL58075 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL58744 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL60636 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL57900 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL301628 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL57829 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL61260 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL56652 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL57459 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL60632 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL60582 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL292621 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL441616 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL58917 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL294638 | — | IC50 | < | 2.0 | nM | - |