Assay Detail
Functional
CHEMBL668137
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In vitro inhibitory activity was evaluated against dog squalence epoxidase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.17 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537176 | — | — | 1 | 7.85 |
| CHEMBL347699 | — | — | 1 | 7.47 |
| CHEMBL27885 | — | — | 1 | 7.37 |
| CHEMBL348382 | — | — | 1 | 7.29 |
| CHEMBL346067 | — | — | 1 | 7.11 |
| CHEMBL157340 | — | — | 1 | 6.64 |
| CHEMBL159182 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537176 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL347699 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL27885 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL348382 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL346067 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL157340 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL159182 | — | IC50 | = | 370.0 | nM | 6.43 |