Assay Detail
Binding
CHEMBL668240
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Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding and preliminary evaluation of 5-hydroxy- and 10-hydroxy-2,3, 12,12a-tetrahydro-1H-[1]benzoxepino[2,3,4-ij]isoquinolines as dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.81 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.13 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.15 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.74 |
| CHEMBL154301 | — | — | 1 | 6.41 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.38 |
| CHEMBL155351 | — | — | 1 | 5.81 |
| CHEMBL350471 | — | — | 1 | 5.77 |
| CHEMBL349311 | — | — | 1 | 5.61 |
| CHEMBL155208 | — | — | 1 | 5.54 |
| CHEMBL347243 | — | — | 1 | 5.52 |
| CHEMBL436042 | — | — | 1 | 5.46 |
| CHEMBL439639 | — | — | 1 | 5.46 |
| CHEMBL350457 | — | — | 1 | 5.41 |
| CHEMBL154948 | — | — | 1 | 5.37 |
| CHEMBL155352 | — | — | 1 | 5.32 |
| CHEMBL157799 | — | — | 1 | 5.28 |
| CHEMBL422169 | — | — | 1 | 5.25 |
| CHEMBL154468 | — | — | 1 | 5.17 |
| CHEMBL154015 | — | — | 1 | 5.13 |
| CHEMBL156011 | — | — | 1 | 5.12 |
| CHEMBL158067 | — | — | 1 | 4.93 |
| CHEMBL346792 | — | — | 1 | - |
| CHEMBL348465 | — | — | 1 | - |
| CHEMBL155066 | — | — | 1 | - |
| CHEMBL345240 | — | — | 1 | - |
| CHEMBL155002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL53 | APOMORPHINE | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL154301 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL59 | DOPAMINE | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL155351 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL350471 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL349311 | — | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL155208 | — | Ki | = | 2884.03 | nM | 5.54 |
| CHEMBL347243 | — | Ki | = | 3019.95 | nM | 5.52 |
| CHEMBL436042 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL439639 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL350457 | — | Ki | = | 3890.45 | nM | 5.41 |
| CHEMBL154948 | — | Ki | = | 4265.8 | nM | 5.37 |
| CHEMBL155352 | — | Ki | = | 4786.3 | nM | 5.32 |
| CHEMBL157799 | — | Ki | = | 5248.07 | nM | 5.28 |
| CHEMBL422169 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL154468 | — | Ki | = | 6760.83 | nM | 5.17 |
| CHEMBL154015 | — | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL156011 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL158067 | — | Ki | = | 11748.98 | nM | 4.93 |
| CHEMBL346792 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL348465 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL155066 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL345240 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL155002 | — | Ki | < | 10000.0 | nM | - |