Assay Detail
Functional
CHEMBL668341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to block isoproterenol-induced contractile force in anesthetized dogs.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.34 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104734 | — | — | 1 | 8.36 |
| CHEMBL105817 | — | — | 1 | 7.76 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 7.60 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | — | 1 | 7.54 |
| CHEMBL106159 | — | — | 1 | 7.49 |
| CHEMBL420294 | — | — | 1 | 6.97 |
| CHEMBL107345 | — | — | 1 | 6.81 |
| CHEMBL316990 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104734 | — | Kd | = | 4.365 | nM | 8.36 |
| CHEMBL105817 | — | Kd | = | 17.38 | nM | 7.76 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | Kd | = | 28.84 | nM | 7.54 |
| CHEMBL106159 | — | Kd | = | 32.36 | nM | 7.49 |
| CHEMBL420294 | — | Kd | = | 107.15 | nM | 6.97 |
| CHEMBL107345 | — | Kd | = | 154.88 | nM | 6.81 |
| CHEMBL316990 | — | Kd | = | 645.65 | nM | 6.19 |