Assay Detail
Functional
CHEMBL668342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to block isoproterenol-induced increases in heart rate(HR) in anesthetized dogs.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.03 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104734 | — | — | 1 | 8.01 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 7.43 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | — | 1 | 7.34 |
| CHEMBL105817 | — | — | 1 | 7.25 |
| CHEMBL106159 | — | — | 1 | 7.12 |
| CHEMBL107345 | — | — | 1 | 6.64 |
| CHEMBL420294 | — | — | 1 | 6.54 |
| CHEMBL316990 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104734 | — | Kd | = | 9.772 | nM | 8.01 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 37.15 | nM | 7.43 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | Kd | = | 45.71 | nM | 7.34 |
| CHEMBL105817 | — | Kd | = | 56.23 | nM | 7.25 |
| CHEMBL106159 | — | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL107345 | — | Kd | = | 229.09 | nM | 6.64 |
| CHEMBL420294 | — | Kd | = | 288.4 | nM | 6.54 |
| CHEMBL316990 | — | Kd | = | 1348.96 | nM | 5.87 |