Assay Detail
Binding
CHEMBL668393
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Evaluated for inhibition of dihydrofolate reductase (DHFR) from Lactobacillus casei
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.80 |
| CHEMBL69016 | — | — | 1 | 7.64 |
| CHEMBL66864 | — | — | 1 | 4.80 |
| CHEMBL267890 | — | — | 1 | 4.72 |
| CHEMBL66389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL69016 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL66864 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL267890 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL66389 | — | IC50 | > | 100000.0 | nM | - |