Assay Detail
Binding
CHEMBL668635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.62 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.52 |
| CHEMBL304535 | — | — | 1 | 9.40 |
| CHEMBL444321 | — | — | 1 | 9.10 |
| CHEMBL303012 | — | — | 1 | 8.80 |
| CHEMBL307790 | — | — | 1 | 8.15 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL304535 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL444321 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL303012 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL307790 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL59 | DOPAMINE | Ki | = | 192.0 | nM | 6.72 |