Assay Detail
Binding
CHEMBL668642
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Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.34 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.37 |
| CHEMBL303993 | — | — | 1 | 8.18 |
| CHEMBL64117 | — | — | 1 | 7.57 |
| CHEMBL302393 | — | — | 1 | 7.06 |
| CHEMBL65397 | — | — | 1 | 6.85 |
| CHEMBL293828 | — | — | 1 | 6.75 |
| CHEMBL59603 | — | — | 1 | 6.55 |
| CHEMBL293158 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL303993 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL64117 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL302393 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL65397 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL293828 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL59603 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL293158 | — | Ki | = | 446.68 | nM | 6.35 |