Assay Detail
Binding
CHEMBL668775
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Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductase
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.00 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 7.43 |
| CHEMBL1160541 | — | — | 1 | 6.52 |
| CHEMBL82334 | — | — | 1 | 6.38 |
| CHEMBL310759 | — | — | 2 | 6.29 |
| CHEMBL85364 | — | — | 1 | 6.21 |
| CHEMBL83547 | — | — | 1 | 6.09 |
| CHEMBL84108 | — | — | 1 | 5.96 |
| CHEMBL82825 | — | — | 1 | 5.68 |
| CHEMBL309713 | — | — | 1 | 4.80 |
| CHEMBL82985 | — | — | 1 | 4.62 |
| CHEMBL80014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1160541 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL82334 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL310759 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL85364 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL83547 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL310759 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL84108 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL82825 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL309713 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL82985 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL80014 | — | IC50 | = | 120000.0 | nM | - |