Assay Detail
Binding
CHEMBL668779
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The ability to inhibit rat liver Dihydrofolate reductase was tested
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.69 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.82 |
| CHEMBL7375 | — | — | 1 | 7.47 |
| CHEMBL7063 | — | — | 1 | 7.42 |
| CHEMBL267616 | — | — | 1 | 7.20 |
| CHEMBL7571 | — | — | 1 | 7.19 |
| CHEMBL7452 | — | — | 1 | 7.11 |
| CHEMBL266024 | — | — | 1 | 7.10 |
| CHEMBL267207 | — | — | 1 | 7.10 |
| CHEMBL268355 | — | — | 1 | 6.96 |
| CHEMBL7542 | — | — | 1 | 6.96 |
| CHEMBL7779 | — | — | 1 | 6.96 |
| CHEMBL268870 | — | — | 1 | 6.92 |
| CHEMBL7586 | — | — | 1 | 6.89 |
| CHEMBL7062 | — | — | 1 | 6.77 |
| CHEMBL6970 | — | — | 1 | 6.75 |
| CHEMBL267437 | — | — | 1 | 6.72 |
| CHEMBL7170 | — | — | 1 | 6.57 |
| CHEMBL7488 | — | — | 1 | 6.54 |
| CHEMBL7263 | — | — | 1 | 6.25 |
| CHEMBL7139 | — | — | 1 | 5.85 |
| CHEMBL7535 | — | — | 1 | 5.72 |
| CHEMBL6899 | — | — | 1 | 5.66 |
| CHEMBL6696 | — | — | 1 | 5.52 |
| CHEMBL6971 | — | — | 1 | 5.14 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL7375 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL7063 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL267616 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL7571 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL7452 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL266024 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL267207 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL268355 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL7542 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL7779 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL268870 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL7586 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL7062 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL6970 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL267437 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL7170 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL7488 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL7263 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL7139 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL7535 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL6899 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL6696 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL6971 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 130000.0 | nM | - |