Assay Detail
Binding
CHEMBL668782
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Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.54 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333791 | — | — | 1 | 6.96 |
| CHEMBL121947 | — | — | 1 | 6.89 |
| CHEMBL121264 | — | — | 1 | 6.86 |
| CHEMBL120826 | — | — | 1 | 6.80 |
| CHEMBL121319 | — | — | 1 | 6.62 |
| CHEMBL7488 | — | — | 1 | 6.54 |
| CHEMBL120939 | — | — | 1 | 5.83 |
| CHEMBL122704 | — | — | 1 | 5.79 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333791 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL121947 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL121264 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL120826 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL121319 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL7488 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL120939 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL122704 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 133000.0 | nM | - |