Assay Detail
Binding
CHEMBL668783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against purified dihydrofolate reductase from rat
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.95 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.52 |
| CHEMBL121433 | — | — | 1 | 7.47 |
| CHEMBL123122 | — | — | 1 | 7.42 |
| CHEMBL121348 | — | — | 1 | 7.33 |
| CHEMBL123043 | — | — | 1 | 7.17 |
| CHEMBL121683 | — | — | 1 | 7.15 |
| CHEMBL120821 | — | — | 1 | 7.13 |
| CHEMBL264548 | — | — | 1 | 6.94 |
| CHEMBL120994 | — | — | 1 | 6.82 |
| CHEMBL123276 | — | — | 1 | 6.64 |
| CHEMBL121868 | — | — | 1 | 6.58 |
| CHEMBL7263 | — | — | 1 | 6.25 |
| CHEMBL420332 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL121433 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL123122 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL121348 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL123043 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL121683 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL120821 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL264548 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL120994 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL123276 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL121868 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL7263 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL420332 | — | IC50 | = | 12700.0 | nM | 4.90 |