Assay Detail
Binding
CHEMBL668876
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In vitro inhibitory concentration against rat liver dihydrofolate reductase(DHFR)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 8. Synthesis, crystal structure, and biological properties of a new series of 2,4-diamino-5-aryl-6-ethylpyrimidine dihydrofolate reductase inhibitors with in vivo activity against a methotrexate-resistant tumor cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312667 | — | — | 1 | 7.70 |
| CHEMBL59530 | — | — | 1 | 7.10 |
| CHEMBL79407 | — | — | 1 | 7.00 |
| CHEMBL81552 | — | — | 1 | 6.36 |
| CHEMBL82208 | — | — | 1 | 5.77 |
| CHEMBL79279 | — | — | 1 | 5.51 |
| CHEMBL79465 | — | — | 1 | 5.41 |
| CHEMBL263275 | — | — | 1 | 5.40 |
| CHEMBL309217 | — | — | 1 | 5.21 |
| CHEMBL80110 | — | — | 1 | 5.10 |
| CHEMBL80067 | — | — | 1 | 5.07 |
| CHEMBL82464 | — | — | 1 | 5.04 |
| CHEMBL314593 | — | — | 1 | 4.17 |
| CHEMBL83283 | — | — | 1 | - |
| CHEMBL311176 | — | — | 1 | - |
| CHEMBL439949 | — | — | 1 | - |
| CHEMBL79883 | — | — | 1 | - |
| CHEMBL79417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312667 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL59530 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL79407 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL81552 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL82208 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL79279 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL79465 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL263275 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL309217 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL80110 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL80067 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL82464 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL314593 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL83283 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL311176 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL439949 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL79883 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL79417 | — | IC50 | > | 25000.0 | nM | - |