Assay Detail
Binding
CHEMBL668917
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Tested for ability to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 4(5)-imidazolyl allylamines and propargylamines as inhibitors of diamine oxidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.25 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 6.85 |
| CHEMBL330979 | — | — | 1 | 6.77 |
| CHEMBL119195 | — | — | 1 | 6.70 |
| CHEMBL116536 | — | — | 1 | 5.77 |
| CHEMBL116538 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225304 | PIMAGEDINE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL330979 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL119195 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL116536 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL116538 | — | Ki | = | 7100.0 | nM | 5.15 |