Assay Detail
Binding
CHEMBL668983
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Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.15 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164747 | — | — | 1 | 7.26 |
| CHEMBL24510 | FUSARIC ACID | — | 1 | 6.83 |
| CHEMBL1515 | METHIMAZOLE | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164747 | — | Ki | = | 54.9 | nM | 7.26 |
| CHEMBL24510 | FUSARIC ACID | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL1515 | METHIMAZOLE | Ki | = | 45000.0 | nM | 4.35 |