Assay Detail
Binding
CHEMBL669017
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Concentration inhibiting rat liver dihydrofolate reductase.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.70 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.82 |
| CHEMBL23532 | — | — | 1 | 8.68 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.52 |
| CHEMBL88555 | — | — | 1 | 8.23 |
| CHEMBL50514 | — | — | 1 | 8.12 |
| CHEMBL328897 | — | — | 1 | 7.92 |
| CHEMBL89528 | — | — | 1 | 7.66 |
| CHEMBL52688 | — | — | 1 | 7.58 |
| CHEMBL300603 | — | — | 1 | 7.50 |
| CHEMBL82975 | — | — | 1 | 7.38 |
| CHEMBL88430 | — | — | 1 | 7.36 |
| CHEMBL54399 | — | — | 1 | 7.17 |
| CHEMBL55179 | — | — | 1 | 6.52 |
| CHEMBL52947 | — | — | 1 | 6.37 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL23532 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL88555 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL50514 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL328897 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL89528 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL52688 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL300603 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL82975 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL88430 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL54399 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL55179 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL52947 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 130000.0 | nM | - |