Assay Detail
Binding
CHEMBL669018
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Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.46 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280378 | EPIROPRIM | 2.0 | 1 | 6.80 |
| CHEMBL284544 | — | — | 1 | 6.11 |
| CHEMBL83553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280378 | EPIROPRIM | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL284544 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL83553 | — | IC50 | = | 250000.0 | nM | - |