Assay Detail
Binding
CHEMBL669028
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Inhibition of rat liver dihydrofolate reductase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.28 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.82 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.52 |
| CHEMBL421594 | — | — | 1 | 6.05 |
| CHEMBL102303 | — | — | 1 | 5.80 |
| CHEMBL103474 | — | — | 1 | 5.73 |
| CHEMBL106070 | — | — | 1 | 5.46 |
| CHEMBL105759 | — | — | 1 | 5.43 |
| CHEMBL105523 | — | — | 1 | 5.16 |
| CHEMBL318601 | — | — | 1 | 4.96 |
| CHEMBL431257 | — | — | 1 | 4.89 |
| CHEMBL106383 | — | — | 1 | 4.89 |
| CHEMBL105020 | — | — | 1 | 4.82 |
| CHEMBL317618 | — | — | 1 | 4.75 |
| CHEMBL101378 | — | — | 1 | 4.60 |
| CHEMBL102432 | — | — | 1 | 4.54 |
| CHEMBL103108 | — | — | 1 | 4.53 |
| CHEMBL103203 | — | — | 1 | 4.52 |
| CHEMBL105323 | — | — | 1 | 4.49 |
| CHEMBL102444 | — | — | 1 | 4.47 |
| CHEMBL102518 | — | — | 1 | 4.28 |
| CHEMBL66077 | — | — | 1 | 4.22 |
| CHEMBL101908 | — | — | 1 | - |
| CHEMBL312688 | — | — | 1 | - |
| CHEMBL105906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL421594 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL102303 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL103474 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL106070 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL105759 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL105523 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL318601 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL431257 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL106383 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL105020 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL317618 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL101378 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL102432 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL103108 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL103203 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL105323 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL102444 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL102518 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL66077 | — | IC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL101908 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL312688 | — | IC50 | = | 252000.0 | nM | - |
| CHEMBL105906 | — | IC50 | = | 280000.0 | nM | - |