Assay Detail
Binding
CHEMBL669071
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Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.75 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64875 | — | — | 1 | 8.92 |
| CHEMBL303313 | — | — | 1 | 8.66 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 8.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64875 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL303313 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL64249 | CLOROTEPINE | IC50 | = | 2.2 | nM | 8.66 |