Assay Detail
Binding
CHEMBL669143
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In vitro binding affinity for D2/D3 receptors in rat striatal homogenates by [125I]NCQ298 displacement.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Dopamine receptor D2 and D3 (CHEMBL2111342) ↗| Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
Publication
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.18 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340816 | — | — | 1 | 7.79 |
| CHEMBL341139 | — | — | 1 | 7.60 |
| CHEMBL405524 | — | — | 1 | 7.25 |
| CHEMBL339863 | — | — | 1 | 5.83 |
| CHEMBL126762 | — | — | 1 | 5.71 |
| CHEMBL127365 | — | — | 1 | 5.58 |
| CHEMBL125795 | — | — | 1 | 5.47 |
| CHEMBL339281 | — | — | 1 | 5.29 |
| CHEMBL127790 | — | — | 1 | 5.06 |
| CHEMBL87594 | — | — | 1 | - |
| CHEMBL315146 | — | — | 1 | - |
| CHEMBL340185 | — | — | 1 | - |
| CHEMBL87414 | — | — | 1 | - |
| CHEMBL126488 | — | — | 1 | - |
| CHEMBL339491 | — | — | 1 | - |
| CHEMBL314170 | — | — | 1 | - |
| CHEMBL126257 | — | — | 1 | - |
| CHEMBL127180 | — | — | 1 | - |
| CHEMBL338411 | — | — | 1 | - |
| CHEMBL340815 | — | — | 1 | - |
| CHEMBL126019 | — | — | 1 | - |
| CHEMBL338140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340816 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL341139 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL405524 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL339863 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL126762 | — | Ki | = | 1967.0 | nM | 5.71 |
| CHEMBL127365 | — | Ki | = | 2658.0 | nM | 5.58 |
| CHEMBL125795 | — | Ki | = | 3385.0 | nM | 5.47 |
| CHEMBL339281 | — | Ki | = | 5092.0 | nM | 5.29 |
| CHEMBL127790 | — | Ki | = | 8795.0 | nM | 5.06 |
| CHEMBL87594 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL315146 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL340185 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL87414 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL126488 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL339491 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL314170 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL126257 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL127180 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL338411 | — | Ki | > | 38000.0 | nM | - |
| CHEMBL340815 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL126019 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL338140 | — | Ki | > | 1000.0 | nM | - |