Assay Detail
Binding
CHEMBL669355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of dihydrofolate reductase in Bovine liver
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.39 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.89 |
| CHEMBL41056 | — | — | 1 | 8.60 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 8.42 |
| CHEMBL42159 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL41056 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL42159 | — | IC50 | = | 22.0 | nM | 7.66 |