Assay Detail
Binding
CHEMBL669468
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In vitro inhibitory concentration against beef liver dihydrofolate reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.28 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124631 | — | — | 1 | 7.37 |
| CHEMBL173271 | — | — | 1 | 7.15 |
| CHEMBL350097 | — | — | 1 | 4.31 |
| CHEMBL170101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124631 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL173271 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL350097 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL170101 | — | IC50 | = | 560000.0 | nM | - |