Assay Detail
Binding
CHEMBL669620
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In vitro inhibitory concentration against rat liver dihydrofolate reductase
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.66 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.52 |
| CHEMBL56170 | — | — | 1 | 8.49 |
| CHEMBL59530 | — | — | 1 | 7.82 |
| CHEMBL57222 | — | — | 1 | 7.50 |
| CHEMBL299045 | — | — | 1 | 6.48 |
| CHEMBL55584 | — | — | 1 | 6.36 |
| CHEMBL54659 | — | — | 1 | 6.30 |
| CHEMBL57610 | — | — | 1 | 6.24 |
| CHEMBL293822 | — | — | 1 | 6.05 |
| CHEMBL293265 | — | — | 1 | 5.96 |
| CHEMBL55903 | — | — | 1 | 5.77 |
| CHEMBL56862 | — | — | 1 | 5.75 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.64 |
| CHEMBL53902 | — | — | 1 | 5.64 |
| CHEMBL55526 | — | — | 1 | 5.46 |
| CHEMBL440479 | — | — | 1 | 5.30 |
| CHEMBL298538 | — | — | 1 | 5.16 |
| CHEMBL56532 | — | — | 1 | 5.14 |
| CHEMBL56311 | — | — | 1 | 5.11 |
| CHEMBL54007 | — | — | 1 | 4.99 |
| CHEMBL413323 | — | — | 1 | 4.79 |
| CHEMBL56861 | — | — | 1 | 4.76 |
| CHEMBL300876 | — | — | 1 | 4.75 |
| CHEMBL49246 | — | — | 1 | 4.72 |
| CHEMBL55764 | — | — | 1 | 4.71 |
| CHEMBL298819 | — | — | 1 | 4.58 |
| CHEMBL48203 | — | — | 1 | 4.58 |
| CHEMBL56456 | — | — | 1 | 4.57 |
| CHEMBL56709 | — | — | 1 | 4.55 |
| CHEMBL293321 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL56170 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL59530 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL57222 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL299045 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL55584 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL54659 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL57610 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL293822 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL293265 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL55903 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL56862 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL53902 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL55526 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL440479 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL298538 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL56532 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL56311 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL54007 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL413323 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL56861 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL300876 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL49246 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL55764 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL298819 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL48203 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL56456 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL56709 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL293321 | — | IC50 | = | 66800.0 | nM | 4.17 |
| CHEMBL55697 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL294468 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL56169 | — | IC50 | = | 202000.0 | nM | - |
| CHEMBL56366 | — | IC50 | > | 11000.0 | nM | - |