Assay Detail
Binding
CHEMBL669680
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Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.63 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.20 |
| CHEMBL73538 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL73538 | — | IC50 | = | 895.0 | nM | 6.05 |