Assay Detail
Binding
CHEMBL669681
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Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.88 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.35 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 6.19 |
| CHEMBL322574 | — | — | 1 | 6.01 |
| CHEMBL106622 | — | — | 1 | 5.89 |
| CHEMBL288096 | — | — | 1 | 5.76 |
| CHEMBL106886 | — | — | 1 | 5.51 |
| CHEMBL53294 | — | — | 1 | 5.48 |
| CHEMBL107041 | — | — | 1 | - |
| CHEMBL107519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL322574 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL106622 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL288096 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL106886 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL53294 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL107041 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL107519 | — | IC50 | > | 10000.0 | nM | - |