Assay Detail
Binding
CHEMBL669834
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Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.85 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.47 |
| CHEMBL85879 | — | — | 1 | 5.55 |
| CHEMBL112037 | — | — | 1 | 5.52 |
| CHEMBL325238 | — | — | 1 | - |
| CHEMBL115508 | — | — | 1 | - |
| CHEMBL112124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL85879 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL112037 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL325238 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115508 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL112124 | — | IC50 | > | 10000.0 | nM | - |