Assay Detail
Binding
CHEMBL669836
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Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A structure-activity study of four dopamine D-1 and D-2 receptor antagonists, representing the phenylindan, -indene, and -indole structural classes of compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.00 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 8.66 |
| CHEMBL318714 | — | — | 1 | 8.02 |
| CHEMBL12507 | — | — | 1 | 8.01 |
| CHEMBL317982 | — | — | 1 | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 7.72 |
| CHEMBL319810 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL318714 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL12507 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL317982 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL319810 | — | IC50 | = | 23.0 | nM | 7.64 |