Assay Detail
Binding
CHEMBL670035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]WIN-35428 binding to Dopamine transporter
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.85 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306208 | — | — | 2 | 8.95 |
| CHEMBL14391 | — | — | 2 | 8.90 |
| CHEMBL82027 | — | — | 2 | 8.77 |
| CHEMBL2079586 | — | — | 2 | 7.85 |
| CHEMBL1790051 | — | — | 2 | 7.64 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL340560 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306208 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL14391 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL82027 | — | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL306208 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL14391 | — | IC50 | = | 2.85 | nM | 8.54 |
| CHEMBL82027 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL2079586 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2079586 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL1790051 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL340560 | — | IC50 | = | 6160.0 | nM | 5.21 |