Assay Detail
Binding
CHEMBL670038
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Inhibition of [3H]WIN-35428l binding to Dopamine transporter
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.14 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82946 | — | — | 1 | 9.37 |
| CHEMBL610897 | — | — | 1 | 8.93 |
| CHEMBL311347 | — | — | 1 | 8.90 |
| CHEMBL82093 | — | — | 1 | 8.85 |
| CHEMBL313038 | — | — | 1 | 8.82 |
| CHEMBL312037 | — | — | 1 | 8.77 |
| CHEMBL310573 | — | — | 1 | 8.70 |
| CHEMBL86165 | — | — | 1 | 8.48 |
| CHEMBL309635 | — | — | 1 | 8.28 |
| CHEMBL2079586 | — | — | 1 | 7.80 |
| CHEMBL83729 | — | — | 1 | 7.64 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.99 |
| CHEMBL314464 | — | — | 1 | 6.95 |
| CHEMBL310131 | — | — | 1 | 6.89 |
| CHEMBL314465 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82946 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL610897 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL311347 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL82093 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL313038 | — | IC50 | = | 1.51 | nM | 8.82 |
| CHEMBL312037 | — | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL310573 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL86165 | — | IC50 | = | 3.27 | nM | 8.48 |
| CHEMBL309635 | — | IC50 | = | 5.29 | nM | 8.28 |
| CHEMBL2079586 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL83729 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL370805 | COCAINE | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL314464 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL310131 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL314465 | — | IC50 | = | 211.0 | nM | 6.68 |