Assay Detail
Binding
CHEMBL670099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at human Dopamine receptor D4.4 by [3H]YM-09151-2 displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.49 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93403 | — | — | 1 | 10.40 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.00 |
| CHEMBL327245 | — | — | 1 | 8.40 |
| CHEMBL92713 | — | — | 1 | 8.27 |
| CHEMBL92121 | — | — | 1 | 7.68 |
| CHEMBL96462 | — | — | 1 | 7.64 |
| CHEMBL315879 | — | — | 1 | 7.60 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.52 |
| CHEMBL2112375 | — | — | 1 | 7.50 |
| CHEMBL329228 | — | — | 1 | 7.38 |
| CHEMBL96799 | — | — | 1 | 7.38 |
| CHEMBL328283 | — | — | 1 | 7.34 |
| CHEMBL330470 | — | — | 1 | 6.85 |
| CHEMBL92411 | — | — | 1 | 6.75 |
| CHEMBL318747 | — | — | 1 | 6.69 |
| CHEMBL94265 | — | — | 1 | 6.62 |
| CHEMBL96322 | — | — | 1 | 6.55 |
| CHEMBL420067 | — | — | 1 | 6.41 |
| CHEMBL321557 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93403 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL327245 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL92713 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL92121 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL96462 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL315879 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL42 | CLOZAPINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2112375 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL329228 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL96799 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL328283 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL330470 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL92411 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL318747 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL94265 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL96322 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL420067 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL321557 | — | Ki | = | 416.0 | nM | 6.38 |