Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL94265

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1cccc(C(=O)NCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1

Basic Information

ChEMBL ID CHEMBL94265
Phase Preclinical
Structure Type MOL
InChI Key WHRQYYUJQYMCLD-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

416.0
MW (Da)
4.07
ALogP
4
HBA
1
HBD
44.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H30ClN3O2
MW 415.97
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -1.59

Activity Summary

Ki 5 meas. best 7.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL3138
Ki 7.44 7.44 36.0 1
D(4) dopamine receptor
CHEMBL219
Ki 6.62 6.62 241.0 2
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 6.33 6.33 470.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10649982 10.1021/jm991138z D(2) dopamine receptor 2
10649982 10.1021/jm991138z 5-hydroxytryptamine receptor 1A 2
12477356 10.1021/jm020952a D(2) dopamine receptor 2
12477356 10.1021/jm020952a 5-hydroxytryptamine receptor 1A 2
10649982 10.1021/jm991138z D(4) dopamine receptor 1
10649982 10.1021/jm991138z Adrenergic receptor alpha-1 1
12477356 10.1021/jm020952a D(3) dopamine receptor 1
12477356 10.1021/jm020952a D(4) dopamine receptor 1
12477356 10.1021/jm020952a Adrenergic receptor alpha-1 1
12477356 10.1021/jm020952a No relevant target 1

Data from ChEMBL 36 via Core Engine