Assay Detail
Binding
CHEMBL647023
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Binding affinity towards Alpha-1 adrenergic receptor from rat cortical membranes
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 6.65 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154508 | — | — | 1 | 8.30 |
| CHEMBL345848 | — | — | 1 | 8.14 |
| CHEMBL152869 | — | — | 1 | 7.79 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.75 |
| CHEMBL157322 | — | — | 1 | 7.75 |
| CHEMBL152159 | — | — | 1 | 7.58 |
| CHEMBL152756 | — | — | 1 | 7.24 |
| CHEMBL357448 | — | — | 1 | 7.21 |
| CHEMBL152576 | — | — | 1 | 7.18 |
| CHEMBL347290 | — | — | 1 | 7.04 |
| CHEMBL196476 | — | — | 1 | 6.96 |
| CHEMBL345111 | — | — | 1 | 6.94 |
| CHEMBL154050 | — | — | 1 | 6.87 |
| CHEMBL152391 | — | — | 1 | 6.87 |
| CHEMBL152304 | — | — | 1 | 6.86 |
| CHEMBL286725 | — | — | 1 | 6.75 |
| CHEMBL157222 | — | — | 1 | 6.71 |
| CHEMBL157388 | — | — | 1 | 6.65 |
| CHEMBL2112911 | — | — | 1 | 6.63 |
| CHEMBL93403 | — | — | 1 | 6.61 |
| CHEMBL147483 | — | — | 1 | 6.55 |
| CHEMBL315879 | — | — | 1 | 6.39 |
| CHEMBL156599 | — | — | 1 | 6.37 |
| CHEMBL92713 | — | — | 1 | 6.36 |
| CHEMBL156845 | — | — | 1 | 6.34 |
| CHEMBL94265 | — | — | 1 | 6.33 |
| CHEMBL2112910 | — | — | 1 | 6.18 |
| CHEMBL433741 | — | — | 1 | 6.14 |
| CHEMBL152587 | — | — | 1 | 5.95 |
| CHEMBL152010 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154508 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL345848 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL152869 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL597 | PHENTOLAMINE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL157322 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL152159 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL152756 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL357448 | — | Ki | = | 61.4 | nM | 7.21 |
| CHEMBL152576 | — | Ki | = | 66.7 | nM | 7.18 |
| CHEMBL347290 | — | Ki | = | 92.1 | nM | 7.04 |
| CHEMBL196476 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL345111 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL154050 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL152391 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL152304 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL286725 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL157222 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL157388 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL2112911 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL93403 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL147483 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL315879 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL156599 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL92713 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL156845 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL94265 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL2112910 | — | Ki | = | 656.0 | nM | 6.18 |
| CHEMBL433741 | — | Ki | = | 717.0 | nM | 6.14 |
| CHEMBL152010 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL152587 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL152262 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL346692 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL2112905 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL423040 | — | Ki | = | 3119.0 | nM | 5.51 |
| CHEMBL345820 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL152679 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL61789 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL305362 | — | Ki | > | 1000.0 | nM | - |