Assay Detail
Binding
CHEMBL646572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards alpha-1 adrenergic receptor by using [3H]prazosin in rat brain cortex membranes.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.39 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92121 | — | — | 1 | 6.84 |
| CHEMBL93403 | — | — | 1 | 6.61 |
| CHEMBL329228 | — | — | 1 | 6.52 |
| CHEMBL315879 | — | — | 1 | 6.39 |
| CHEMBL94265 | — | — | 1 | 6.33 |
| CHEMBL96799 | — | — | 1 | 6.20 |
| CHEMBL96322 | — | — | 1 | 6.17 |
| CHEMBL327245 | — | — | 1 | 6.04 |
| CHEMBL328283 | — | — | 1 | - |
| CHEMBL330470 | — | — | 1 | - |
| CHEMBL318747 | — | — | 1 | - |
| CHEMBL92411 | — | — | 1 | - |
| CHEMBL321557 | — | — | 1 | - |
| CHEMBL2112375 | — | — | 1 | - |
| CHEMBL420067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92121 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL93403 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL329228 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL315879 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL94265 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL96799 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL96322 | — | Ki | = | 678.0 | nM | 6.17 |
| CHEMBL327245 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL328283 | — | Ki | > | 850.0 | nM | - |
| CHEMBL330470 | — | Ki | > | 850.0 | nM | - |
| CHEMBL318747 | — | Ki | > | 850.0 | nM | - |
| CHEMBL92411 | — | Ki | > | 850.0 | nM | - |
| CHEMBL321557 | — | Ki | > | 850.0 | nM | - |
| CHEMBL2112375 | — | Ki | > | 850.0 | nM | - |
| CHEMBL420067 | — | Ki | > | 850.0 | nM | - |