Assay Detail
Binding
CHEMBL670102
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Binding affinity at cloned human Dopamine receptor D4 expressed in HEK 293 cells, using [3H]nemonapride as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-(substituted-phenyl) piperazines: antagonists with high binding and functional selectivity for dopamine D4 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.37 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21168 | — | — | 1 | 8.30 |
| CHEMBL283353 | — | — | 1 | 8.10 |
| CHEMBL20655 | — | — | 1 | 8.10 |
| CHEMBL20725 | — | — | 1 | 8.10 |
| CHEMBL20367 | — | — | 1 | 8.00 |
| CHEMBL20493 | — | — | 1 | 7.90 |
| CHEMBL21008 | — | — | 1 | 7.90 |
| CHEMBL20444 | — | — | 1 | 7.90 |
| CHEMBL21011 | — | — | 1 | 7.80 |
| CHEMBL20251 | — | — | 1 | 7.80 |
| CHEMBL21119 | — | — | 1 | 7.70 |
| CHEMBL282008 | — | — | 1 | 7.60 |
| CHEMBL20996 | — | — | 1 | 7.50 |
| CHEMBL277669 | — | — | 1 | 7.50 |
| CHEMBL21059 | — | — | 1 | 7.30 |
| CHEMBL20854 | — | — | 1 | 7.20 |
| CHEMBL20204 | — | — | 1 | 7.20 |
| CHEMBL283142 | — | — | 1 | 7.10 |
| CHEMBL20729 | — | — | 1 | 7.00 |
| CHEMBL20114 | — | — | 1 | 6.90 |
| CHEMBL278288 | — | — | 1 | 6.90 |
| CHEMBL277937 | — | — | 1 | 6.90 |
| CHEMBL21205 | — | — | 1 | 6.80 |
| CHEMBL423287 | — | — | 1 | 6.70 |
| CHEMBL20819 | — | — | 1 | 6.50 |
| CHEMBL21035 | — | — | 1 | 6.50 |
| CHEMBL21252 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21168 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL283353 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL20655 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL20725 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL20367 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20493 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL21008 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL20444 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL21011 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL20251 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL21119 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL282008 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL20996 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL277669 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL21059 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL20854 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL20204 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL283142 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL20729 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL20114 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL278288 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL277937 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL21205 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL423287 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL20819 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL21035 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL21252 | — | Ki | = | 1258.93 | nM | 5.90 |