Assay Detail
Binding
CHEMBL670137
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Evaluated for binding towards Dopamine receptor D2 using [3H]-spiperone as radioligand, in cloned mammalian receptors expressed in CHO-K1 cells
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.12 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.52 |
| CHEMBL278751 | — | — | 1 | 7.75 |
| CHEMBL276500 | — | — | 2 | 6.86 |
| CHEMBL27441 | — | — | 1 | 6.80 |
| CHEMBL90359 | — | — | 1 | 6.75 |
| CHEMBL107492 | — | — | 2 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL278751 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL276500 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL27441 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL90359 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL276500 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL107492 | — | Ki | = | 889.0 | nM | 6.05 |
| CHEMBL107492 | — | Ki | > | 2000.0 | nM | - |