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Assay Detail

CHEMBL670140

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro ability to displace [3H]-spiperone from bovine cloned Dopamine receptor D2 stably expressed in CHO cells.
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL3998)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding.
Lehmann T, Hübner H, Gmeiner P.
Bioorg Med Chem Lett (2001) 11 : 2863 -2866
PubMed 11597417 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 5.15 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316983 2 7.05
CHEMBL440143 1 5.89
CHEMBL96958 1 5.42
CHEMBL97283 1 5.40
CHEMBL318924 1 5.39
CHEMBL95230 1 5.26
CHEMBL98563 1 5.23
CHEMBL95618 1 5.21
CHEMBL98072 1 5.02
CHEMBL97319 1 4.92
CHEMBL97750 1 4.92
CHEMBL323557 1 4.77
CHEMBL97436 1 4.68
CHEMBL98071 1 4.47
CHEMBL99291 1 4.43
CHEMBL96998 1 4.26
CHEMBL97348 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316983 Ki = 90.0 nM 7.05
CHEMBL440143 Ki = 1300.0 nM 5.89
CHEMBL96958 Ki = 3800.0 nM 5.42
CHEMBL97283 Ki = 4000.0 nM 5.40
CHEMBL318924 Ki = 4100.0 nM 5.39
CHEMBL95230 Ki = 5500.0 nM 5.26
CHEMBL98563 Ki = 5900.0 nM 5.23
CHEMBL95618 Ki = 6100.0 nM 5.21
CHEMBL316983 Ki = 6500.0 nM 5.19
CHEMBL98072 Ki = 9600.0 nM 5.02
CHEMBL97750 Ki = 12000.0 nM 4.92
CHEMBL97319 Ki = 12000.0 nM 4.92
CHEMBL323557 Ki = 17000.0 nM 4.77
CHEMBL97436 Ki = 21000.0 nM 4.68
CHEMBL98071 Ki = 34000.0 nM 4.47
CHEMBL99291 Ki = 37000.0 nM 4.43
CHEMBL96998 Ki = 55000.0 nM 4.26
CHEMBL97348 Ki > 100000.0 nM -