Assay Detail
Binding
CHEMBL670142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatum
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.69 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.36 |
| CHEMBL368061 | — | — | 3 | 7.16 |
| CHEMBL354210 | — | — | 2 | 6.96 |
| CHEMBL366388 | — | — | 1 | 6.96 |
| CHEMBL177031 | — | — | 3 | 6.92 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL368061 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL368061 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL354210 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL366388 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL177031 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL354210 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL177031 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL177031 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL368061 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2380.0 | nM | 5.62 |