Assay Detail
Binding
CHEMBL670182
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Binding affinity towards dopamine transporter was determined using DA[3H]WIN-35428 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.17 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298580 | — | — | 1 | 8.89 |
| CHEMBL411433 | — | — | 1 | 8.79 |
| CHEMBL14144 | — | — | 1 | 8.70 |
| CHEMBL116195 | — | — | 1 | 7.90 |
| CHEMBL117735 | — | — | 1 | 7.71 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298580 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL411433 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL14144 | — | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL116195 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL117735 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.0 | nM | 7.05 |