Assay Detail
Functional
CHEMBL670185
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Effect on synaptosomal uptake inhibition of Dopamine transporter
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.90 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203891 | — | — | 2 | 8.05 |
| CHEMBL136562 | — | — | 1 | 7.36 |
| CHEMBL1204285 | — | — | 4 | 7.06 |
| CHEMBL1204138 | — | — | 1 | 7.03 |
| CHEMBL1204347 | — | — | 1 | 6.77 |
| CHEMBL1203860 | — | — | 2 | 6.68 |
| CHEMBL12628 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203891 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1203891 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL136562 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1204285 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1204138 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1204285 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1204347 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1204285 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1203860 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1203860 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL12628 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1204285 | — | IC50 | = | 1800.0 | nM | 5.75 |