Assay Detail
Binding
CHEMBL670187
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Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporter
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.23 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81525 | — | — | 2 | 9.21 |
| CHEMBL80262 | — | — | 2 | 9.08 |
| CHEMBL306208 | — | — | 2 | 8.95 |
| CHEMBL82027 | — | — | 2 | 8.77 |
| CHEMBL80515 | — | — | 2 | 8.36 |
| CHEMBL2079586 | — | — | 2 | 7.80 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81525 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL80262 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL306208 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL82027 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL306208 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL81525 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL80515 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL82027 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL2079586 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL2079586 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL80515 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL80262 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.1 | nM | 7.05 |