Assay Detail
Binding
CHEMBL670188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.89 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237328 | — | — | 1 | 7.17 |
| CHEMBL1237326 | — | — | 1 | 6.55 |
| CHEMBL1237338 | — | — | 1 | 5.24 |
| CHEMBL73461 | IRINDALONE | 2.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237328 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1237326 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1237338 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL73461 | IRINDALONE | IC50 | = | 25000.0 | nM | 4.60 |