Assay Detail
Binding
CHEMBL670189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity of dopamine transporter using [3H]WIN-35428 as radioligand was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99354 | — | — | 1 | 7.84 |
| CHEMBL432814 | — | — | 1 | 6.68 |
| CHEMBL98645 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99354 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL432814 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL98645 | — | IC50 | = | 537.0 | nM | 6.27 |